Peptide Powder Teriparatide

What Is Teriparatide
Peptide powder teriparatide, TPTD, is an artificially synthesized polypeptide at positions 1 to 34 of parathyroid hormone (PTH), which promotes bone anabolism and immune function regulation. It can develop for collarbone-related disorders. It is a synthetic polypeptide hormone composed of endogenous parathyroid hormone, which can regulate bone metabolism, stimulate osteoblasts' activity, and increase bone calcium deposition. Teriparatide is a western medicine that holds water, electrolyte, and acid-base balance medication and electrolyte balance. It can significantly increase bone density and strengthen bones' toughness, improving osteoporosis. Patients can also mix with active vitamin D preparations, calcium supplements, and other drugs for co-treatment and other therapeutic effects in clinical practice. TPTD stimulates bone formation and resorption, reduces the incidence of fractures in postmenopausal women, and increases or decreases the bone mineral density, depending on the mode of administration. In addition, this drug does not inhibit the platelet aggregation response of ADP- or collagen-induced pathways. Teriparatide is the first and only FDA-approved biosynthetic treatment for osteoporosis, which can increase the number and activity of osteoblasts, thereby promoting new bone formation. It can not only significantly increase bone density but also comprehensively rebuild bone microstructure, Comprehensively improve bone strength and significantly reduce the incidence of fractures in patients with osteoporosis. If you are interested in osteoporosis teriparatide powder, contact Xi'an Sonwu. Xi'an Sonwu can provide you with pure teriparatide.

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Where To Buy Teriparatide
Xi'an Sonwu Biotech Co. ltd. is a distributor and manufacturer with over ten years of experience. Xi'an Sonwu has stable cooperation with countries worldwide in Asia, Europe, the Americas, and Oceania. Xi'an Sonwu has always insisted on serving and satisfying every customer well. In addition, Xi'an Sonwu strives to do an excellent job in every detail to minimize costs so customers can get cost-effective products. Based on these, customers have given good feedback on the product. So if you need osteoporosis teriparatide powder, please get in touch with Xi'an Sonwu.
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How Does Teriparatide Work
Peptide powder teriparatide is a human PTH analog with the same structure as the 34 amino acid sequences at the N-terminus of natural PTH. It can bind to specific high-affinity cell surface receptors to exert biological effects. For example, it can bind to PIH1 receptors and play PIH's physiological role in bone and kidney, and there is no adverse effect of C-terminal peptide on bone metabolism. Human PTH is secreted by chief parathyroid cells and contains 84 amino acid single-chain polypeptide proteins. It has essential functions of increasing blood calcium, reducing blood phosphorus, and maintaining the internal environment of extracellular fluid. At the same time, PTH has a two-way regulation effect on bone turnover.
TPTD can mediate bone metabolism by inhibiting osteoblast apoptosis, activating bone lining cells, and enhancing osteoblast differentiation. By regulating the adenylate cyclase-cyclic adenosine phosphate protein kinase A pathway, PHT-I receptors on the surface of osteoblasts, bone lining cells, and bone marrow stromal stem cells are intermittently stimulated to promote the differentiation of osteoblasts and prolong the lifespan of osteoblasts. Stimulates osteoblast cell line proliferation through the phosphate C-cytoplasmic calcium ion-protein kinase C signaling pathway. By inhibiting the transactivation activity of PPARγ, it reduces the differentiation of stromal cells into adipocyte lineage and increases the number of osteoblasts. In addition, it indirectly regulates bone growth by regulating cytokines, such as inducing iGF-1 to combine with osteoblasts, thereby promoting bone formation. Regulates the process of bone formation through the Wnt signaling pathway, thereby increasing bone formation. After one week of application of PTH, osteoblast progenitor cells and immature osteoblasts proliferated and differentiated, inhibiting osteoblasts' apoptosis. It is believed that intermittent administration of PTH in small doses can promote bone formation, and large amounts can promote bone resorption. Studies have found that the N-terminal of PIH can bind to PTH-I receptors distributed on bones and kidneys, affecting osteogenesis; the C-terminal can bind to another type of receptor, exert other biological functions, and even promote the formation of osteocytes apoptosis.

What Is Teriparatide Treatment
1. Treatment of primary osteoporosis
Currently, conventional treatment drugs for primary osteoporosis, such as bisphosphonates, calcitonin, and stack hormones, all achieve the effect of Teriparatide alone or in combination can increase bone mineral density, improve bone microstructure, and reduce fracture risk. Most clinical studies have proved that teriparatide increases bone mineral density dose-dependently.
2. Treatment of secondary osteoporosis
A total of 437 male patients with primary or secondary osteoporosis caused by hypogonadism were screened out by bone density examination. They were randomly divided into the placebo group, the teriparatide one low-dose group, and the teriparatide 1 group. In the peptide two high-dose groups, all patients received elemental calcium and vitamin D treatment for research and analysis. After the 11-month observation period, the BMD of the lumbar spine increased by 5.9% and 9.0% in the teriparatide group 1 and 2 groups, respectively. The BMD of the femoral neck increased by 1.5% and 2.9%, and the adverse reactions in the two groups were high in group 1. In the follow-up study, 350 male osteoporosis patients were followed for 30-42 months. The incidence of vertebral fractures in the teriparatide group was 51% lower than in the placebo group. Therefore, this product is a very promising drug for treating glucocorticoid secondary osteoporosis.

Side Effects Of Teriparatide
1. Cardiovascular system: A drop in blood pressure can be seen. This symptom usually occurs at the first few administrations, and the symptoms can be relieved after taking the prone position, which does not hinder the continuation of treatment.
2. Central nervous system: symptoms such as dizziness, depression, and headache can be seen.
3. Metabolic/endocrine system: Increased blood calcium, increased blood uric acid, and hypoparathyroidism may occur.
4. Musculoskeletal system: leg cramps and arthralgia may occur when this drug treats osteoporosis. 5. Gastrointestinal tract: Nausea occurs.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture and store the products, so it has excellent Stock. Xi'an Sonwu has an orderly and clean production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu Biotech Co., Ltd strictly checks every step, from material selection, manufacturing, sample testing, personnel professionalism, and other links, from selecting raw materials to pursuing product quality. To ensure every product escort, provide strict data support and after-sales service.

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Besides guaranteeing the product quality, the other most important thing is assist customers receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ
Although there are many drugs for the treatment of osteoporosis, there is no sufficient evidence to show which drug is better in terms of efficacy and safety. Osteoporosis teriparatide powder, with its unique mechanism of promoting bone formation. The definite effect of increasing bone density and the risk of vertebral fractures has brought a breakthrough to treating anti-osteoporosis drugs. Teriparatide can be used as the first choice of medicine and in combination with raloxifene and vitamin D to enhance the curative effect. With further research, teriparatide may become a powerful weapon in the treatment of osteoporosis.
If you interested in teriparatide supplier, just contact Xi'an Sonwu. Click the email then you get high-quality peptide powder teriparatide.
Email: sales@sonwu.com

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